Tescalcin over-expression increases Keratin 18 and 19 in K562 cells

Tescalcin (TESC) has been shown to be essential in mammalian cells as a regulator of intracellular Ca2+. Ca2+ is second messenger functioning many metabolic pathways well cell differentiation, size and the cycle. K562 over-expressing TESC change their morphology adopt adherent properties. Considering differences may have reflected changes cytoskeleton, we focused on expression levels keratins, which are cytoskeletal intermediate filaments epithelial also expressed K562. We over-expressed gene via lentiviral transduction analyzed keratin 8 (K8), 18 (K18), 19 (K19) expression.